Randomized Clinical Trial Comparing Procedural Amnesia and Respiratory Depression between Moderate versus Deep Sedation with Propofol in the Emergency Department.

Targeting moderate or deep sedation did not reliably result in the intended sedation level. Targeting moderate sedation, however, resulted in a lower rate of total AREs and fewer patients had multiple AREs with no difference in procedural recall. As seen in previous reports, patients who achieved moderate sedation had less AREs than those who achieved deep sedation. Our study suggests that a target of moderate sedation provides adequate amnesia with less need for supportive airway interventions than a target level of deep sedation, despite the fact that it often does not result in intended sedation level. This article is protected by copyright. All rights reserved.