Three‐component Strategy for Synthesis of Dihydropyrido[2,3‐d]pyrimidine and Spirooxindole Derivatives

A series of heterocyclic compound derivatives, including 2,8-diamino-5-aryl-5,10-dihydropyrido[2,3-d:6,5-d]dipyrimidine-4,6(3H,7H)-diones and 2,2-diamino-3H-spiro [pyrimido[4,5-b]quinoline-5,5-pyrrolo[2,3-d]pyrimidine]-4,4,6(3H,7H,10H)-triones, were synthesized via one-pot method using Y (OTf)(3) as catalyst. The reaction was performed in aqueous media using readily available and inexpensive 2,6-diaminopyrimidin-4(3H)-one and aromatic aldehyde as substrates. The present methodology shows attractive characters, such as using water as green reaction media, high catalytic efficiency of catalyst, concise one-pot method, easy work-up/purification, and excellent yields.