Omentin-1 protects against bleomycin-induced acute lung injury.

Yan Zhou,CaiXia Hao,Chen Li,XiaoTing Huang,XiaoHong Li,YiTing Tang,YanHong Huang,SiYuan Tang,Wei Liu,DanDan Feng,JianPing Xu,ShaoJie Yue,Hui Xie,ZiQiang Luo

Molecular Immunology（2018）

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摘要

•Omentin-1 levels decrease in the lung tissue of BLM-induced acute lung injury mice.•Omentin-1 overexpression protects against BLM-induced acute lung injury by exerting anti-inflammatory effects.•Omentin-1 prevents BLM-induced acute lung injury associated with prevention of NF-κB pathway activation.

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关键词

ALI,BLM,TNF-α,LPS,MCP-1,IL-1β,NF-κB,ROS,Ad-omentin-1,Ad-β-gal,BALF,H&E,ELISA,qPCR,MDA,SOD,mtROS,IκB

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