Maximum Tolerated Dose and Pharmacokinetics of Paclitaxel Micellar in Patients with Recurrent Malignant Solid Tumours: A Dose-Escalation Study

Olof Borgå,Roger Henriksson,Helena Bjermo,Elsa Lilienberg,Nina Heldring,Niklas Loman

Advances in therapy（2019）

引用 24|浏览6

暂无评分

摘要

A water-soluble Cremophor EL-free formulation of paclitaxel, in which retinoic acid derivates solubilize paclitaxel by forming micelles (paclitaxel micellar), was studied for the first time in man to establish the maximum tolerated dose (MTD) and to characterize the pharmacokinetics (PK).

查看译文

关键词

Cancer,Dose-finding,First-in-man,Nano-sized micelles,Paclitaxel micellar,Paclitaxel,XR17,Pharmacokinetics

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要