Molecular Alterations of Nucleocytoplasmic Transport in Patients on the Heart Transplantation Waiting List and Its Correlation With the Severity and Etiology of Heart Failure.

•In the myocardiocytes of patients with advanced heart failure, there are alterations in the nuclear-cytoplasmic transport that involve several important molecules (importins, exportins, etc).•Identifying these alterations can help us to better understand the pathophysiology of advanced heart failure and its clinical evolution toward the need for circulatory assistance and later toward heart transplantation.•The presence of different patterns of alterations according to the etiology and severity of advanced heart failure will be a good marker to identify early those patients whose evolution in the short term may be worse, with the need for implantation of a circulatory assistance as a bridge to transplantation.