A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets.

Juan Bayo,Esteban J Fiore,Luciana M Dominguez, Alejandrina Real,Mariana Malvicini,Manglio Rizzo,Catalina Atorrasagasti,Mariana G García,Josepmaria Argemi,Elisabeth D Martinez,Guillermo D Mazzolini

Journal of Hepatology（2019）

引用 75|浏览30

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摘要

•Mutations and expression alterations of epigenetic modifiers are frequent in HCC.•Jumonji lysine demethylase inhibitors normalize aggressive transcription programs in HCC.•CENPA, KIF20A, NCAPG and PLK1 gene expression signature defines prognosis in HCC.•Epigenetic inhibitors are a potential new therapeutic tool for HCC.

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关键词

Human hepatocellular carcinoma,Epigenetic,Histone demethylases,Lysine demethylases,Jumonji C demethylases,Histone methyltransferases,Histone acetyltransferases,Bromodomains,Epigenetic inhibitors,Gene expression signature,Patient survival

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