Morphometric and Computational Assessments to Evaluate Neuron Survival and Maturation Within Compartmentalized Microfluidic Devices: the Influence of Design Variation on Diffusion-Driven Nutrient Transport

Angela R. Dixon,Eric N. Horst, Jeniffer J. Garcia, Patricia R. Ndjouyep-Yamaga,Geeta Mehta

Neuroscience Letters（2019）

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摘要

•Design of Campenot-like microfluidic devices impacts neuron survival and maturation.•Computer simulations reveal distinct device design-dependent NGF transport profiles.•Spatiotemporal NGF depletion is highly tuned by device geometry and cell density.

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关键词

Rat pheochromocytoma PC12 cell line,Microfluidic devices,Nerve growth factor (NGF),Cell viability,Nutrient depletion,Mass transport

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