External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort.

Marije Lamain-de Ruiter,Anneke Kwee,Christiana A Naaktgeboren, Rebecca D Louhanepessy, Inge De Groot,Inge M Evers,Floris Groenendaal,Yolanda R Hering,Anjoke J M Huisjes,Cornel Kirpestein,Wilma M Monincx,Peter C J I Schielen,Annewil Van 't Zelfde, Charlotte M Van Oirschot, Simone A Vankan-Buitelaar, Mariska A A W Vonk,Therese A Wiegers,Joost J Zwart,Karel G M Moons,Arie Franx,Maria P H Koster

HYPERTENSION IN PREGNANCY（2019）

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摘要

Objective: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). Methods: Women Results: 3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. Conclusion: Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.

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关键词

First trimester,preeclampsia,external validation,prognostic model

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