Timosaponin AIII, a Steroidal Saponin, Exhibits Anti-Tumor Effect on Taxol-Resistant Cells in Vitro and in Vivo

Xiao-Yu Song,Feng-Ying Han,Jing-Jie Chen,Wei Wang,Yan Zhang,Guo-Dong Yao,Shao-Jiang Song

Steroids（2019）

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摘要

•TAIII could induce apoptosis in two taxol-resistant cancer cell lines.•TAIII reduced the expressions of PI3K/AKT/mTOR and Ras/Raf/MEK/ERK in vitro.•TAIII suppressed tumor growth by apoptosis induction in vivo.•TAIII decreased the expressions of PI3K/AKT/mTOR and Ras/Raf/MEK/ERK in vivo.

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关键词

Timosaponin AIII,Anemarrhena asphodeloides,Taxol-resistant cells,Apoptosis

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