Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis.

Snježana Tomić,Ivana Mrklić,Jasminka Jakić Razumović,Nives Jonjić,Božena Šarčević,Valerija Blažičević, Ilija Jurković, Branka Vrbičić,Nataša Lisica Šikic,Loredana Labinac Peteh,Čedna Tomasović Lončarić,Majda Vučić,Slavko Gašparov,Dražen Švagelj, Sandra Radiković, Ivana Mahovne

Breast disease（2019）

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摘要

Proliferation remains one of the most important parameters for tumor characterization helpful in making clinical decisions, but it should be used with great caution. Standardization of the Ki-67 assessment is essential and proliferating index should be expressed as exact numeric value. For patients with proliferative index near the cut-off value, other factors must be considered in making clinical decisions.

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关键词

Breast cancer,Ki-67,immunohistochemistry,proliferation index

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