Effect of Sulindac in an in vitro AD Model Under hypoxic conditions.

Our results show that the plasmid DNA induced the expression of APP in transfected SHSY5Y cells compared to untransfected cells and the expression of APP was strongest at 24 h. We observed that the cell proliferation decreased in APP transfected cells in both hypoxic and normoxic conditions. Further, reduced cell proliferation was seen under hypoxic conditions compared to normoxic conditions indicating that hypoxic conditions further exacerbateAD pathology. Our findings in an in vitro AD model, suggest that sulindac has a potential therapeutic value to ameliorate AD pathology.