A method for assessing carcinogenic risk of air fine particle-associated polycyclic aromatic hydrocarbons by considering bioaccessibility in lung fluids.
MethodsX(2019)
摘要
This study was conducted to evaluate the inhalation carcinogenic risk of PAHs in biochar fine particles using total concentration-based assessment approach and bioaccessibility-based assessment approach. Only limit PAHs in particles can be released in simulated lung fluids, leading to a low bioaccessibility (only ranging from 0.34% to 1.48% for biochar fine particles and from 3.21% to 44.2% for PM2.5), which would significantly affect health risk assessment. Therefore, bioaccessibility should always be favored over more traditional evaluations based on total concentration, while evaluating inhalation health risks of biochar-bound PAHs. To prove the broad applicability of bioaccessibility-based assessment approaches, we also compared health risk of actual atmospheric particles (PM2.5 collected from Nanjing, China) using total concentration-based approaches and bioaccessibility-based approaches.
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关键词
Bioaccessibility-based approaches for air particle-associated PAHs assessment
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