Early life stress induces type 2 diabetes-like features in ageing mice

H. Ilchmann-Diounou,M. Olier,C. Lencina,A. Riba, S. Barretto,H. Guillou,S. Ellero-Simatos, L. Guzylakc-Piriou,V. Theodorou,S. Menard

Brain, Behavior, and Immunity（2019）

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摘要

•Maternal separation is a risk factor for glucose intolerance in ageing mice.•Maternal separation induces microbiota dysbiosis in favor to pathobionts.•Maternal separation-induced glucose intolerance is associated with decrease of intestinal IL-17 and IL-22 responses.

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DOHaD,FSS,HRP,IBS,MS,OTU,PND,siLP,TCR

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