Severe hypercalcemia complicating granulomatous slack skin disease : An exceptional case.

Granulomatous slack skin disease (GSSD) is a very rare subset of cutaneous T cell lymphoma, clinically characterized by lax skin tumors and wrinkles, mainly in the flexures, groin and buttocks. Histology is characterized by an atypical dermal CD4 positive infiltrate with epidermotropism, a loss of elastic fibers and the presence of epithelioid and giant cell granulomas, We report herein the third case of GSSD-associated hypercalcemia. GSSD was dramatically debilitating with multiple bulky tumoral non-transformed lesions of mycosis fungoides. Hypercalcemia was severe, with calcium levels up to 3,5mM, and refractory to lymphoma treatment. Fluconazole was efficient on hypercalcemia. This article is protected by copyright. All rights reserved.