Beyond Purple Hearts: A Colorful Approach to Isolate Distinct Heart Cells from Human iPSCs.
Cell Stem Cell(2019)
摘要
In this issue of Cell Stem Cell, Zhang et al. (2019) describe a double-reporter iPSC line based on the expression of key cardiac transcription factors, TBX5 and NKX2.5, that delineates cardiac lineage specification in vitro and enables isolation of relatively pure chamber-specific cardiomyocytes, which are critical for drug screening, tissue engineering, and disease modeling.
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