Ultra-sensitive biomolecular detection by external referencing optofluidic microbubble resonators.

We propose an effective method for biomolecular detection based on an external referencing optofluidic microbubble resonator system (EROMBRS), which possesses good long-term stability and low noise. In this study, EROMBRSs were used for nonspecific detection of bovine serum albumin (BSA) molecules and specific detection of D-biotin molecules. Ultra-low practical detection limits of 1 fg/mL for nonspecific and specific biomolecular detection were achieved. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement