Human 3D multicellular microtissues: an upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity.

J Jiang, S Messner,J M Kelm,M van Herwijnen,D G J Jennen, J C Kleinjans,T M de Kok

Toxicology Letters（2019）

引用 16|浏览17

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摘要

•APAP/LPS co-exposure affects mtPC-gene expressions at a lower dose than APAP alone.•APAP exposure reduces KC phagocytosis and increases pro-inflammatory response.•LPS exacerbates APAP-induced liver toxicity.•3D multicellular liver model is useful for studying immune-mediated drug toxicity.

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关键词

3D,ALT,ANOVA,APAP,BP,CAT,CBA,CC,CPDB,DAMPS,DAVID,DEGs,ETC,FACS,FCER1G,FCGR2A,FCGR2B,FCGR2C,FCGR3A,FcγRs,FDR,GO,HCA,IC20,IL,IL1RN,immuneDEGs,KCs,logFC,LPS,MCP-1,MRP,mtDNA,mtPC-DEGs,mtROS,mt-tRNA,NADPH,NAPQI,O2-,OXPHOS,PAMPs,PHH,PRDX3,PRDX5,PRRs,ROS,SOD2,TLR4,TNF,TXNRD2

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