In vivo Non-invasive Diagnosis of Glucose Level in Type-2 Diabetes Mouse by THz Near-Field Imaging

Based on a room-temperature-operated THz fiber-scanning near-field imaging system, we demonstrate in vivo the capability of THz imaging to directly diagnose blood glucose level non-invasively in a type-2 diabetes mouse. High THz absorption induced by higher glucose level facilitates the distinction of blood in mouse ear’s capillary from the surrounding tissues and the THz images reflect a high sensitivity to the change of glucose level in blood. The THz near-field imaging system presented here can have important potential applications in clinical non-invasive human diabetes examination.