Stereoselective Synthesis of New Type of Estradiol Hybrid Molecules and their Antiproliferative Activities.

Anita Kiss,János Wölfling,Erzsébet Mernyák,Éva Frank,András Gyovai,Ágnes Kulmány,István Zupkó,Gyula Schneider

Steroids（2019）

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摘要

•Novel 16-substituted estrone hybrids were synthesized.•Certain compounds proved to be antiproliferative against human cancer cell lines.•The ascorbic or salicylic acid hybrids exerted comparable action to that of cisplatin.

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关键词

3-Methoxy-, 3-Benzyloxy-estra-1,3,5(10)-trienes,Oxetanes,Linker,Hybrid molecules

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