Regulation of Plasma Membrane Localization of the Na⁺-Taurocholate Co-Transporting Polypeptide by Glycochenodeoxycholate and Tauroursodeoxycholate.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology(2019)
摘要
The present study suggests that GCDC triggers the retrieval of Ntcp from the basolateral membrane into the cytosol through an oxidative stress-dependent activation of Fyn. TUDC prevents the GCDC-induced Fyn activation and Ntcp retrieval through integrin-dependent activation of PKA.
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关键词
GCDC,Integrins,Ntcp,Reactive oxygen species,TUDC
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