Mathematical Modelling of a Liver Hollow Fibre Bioreactor.

Ian Sorrell,Rebecca J Shipley,Sophie Regan,Iain Gardner,Michael P Storm,Marianne Ellis,John Ward,Dominic Williams,Pratibha Mistry,José Domingo Salazar,Andrew Scott,Steven Webb

Journal of Theoretical Biology（2019）

引用 22|浏览40

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摘要

•There is an urgent need for more predictive models of hepatotoxicity testing.•Mathematical modelling is used to optimize a hollow fibre liver bioreactor model.•Key parameters that affect xenobiotic clearance are identified.•Analytical results provide a framework for predicting optimal bioreactor set-up.

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关键词

Hollow fibre bioreactor,Liver zonation,Hepatotoxicity testing

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