MP07-13 BASELINE SERUM DEHYDROEPIANDROSTERONE SULFATE (DHEAS) CAN PREDICT RESPONSIVENESS TO PRIMARY ANDROGEN DEPRIVATION THERAPY IN PATIENTS WITH HORMONE NAÏVE METASTATIC PROSTATE CANCER

INTRODUCTION AND OBJECTIVES: The development of prostate cancer (PC) has been associated with numerous lifestyle factors (obesity, physical activity, nutrition) and metabolic perturbations. We aimed to prospectively characterize an integrative metabolic profile of men undergoing diagnostic prostate biopsies. METHODS: We prospectively evaluated 51 consecutive men for body composition, metabolic syndrome, glucoseand lipid-related measures and lifestyle factors including physical function and nutritional intake prior to prostate biopsy. These factors were related to the Gleason score obtained from the extended (16-26 cores) transrectal ultrasound guided biopsy performed for prostate cancer diagnosis. one-way Analysis of Variance (ANOVA) and linear regression were used. RESULTS: Mean age and BMI of the participants were 66 years with and 28.2 kg/m2. Metabolic syndrome was identified in 32 of 51 (63%) participants based on criteria from the International Diabetes Federation. Serum C-peptide concentrations were significantly greater (pu003c0.05) in participants with Gleason scores 7(4+3) or higher (2.8 1.1 ng/mL) compared to those with Gleason scores of 6(3+3) (1.4 0.6 ng/ mL) or Gleason 7(3+4) (1.3 0.8 ng/mL). There were no significant differences in fasting glucose concentrations, but insulin and insulin resistance (HOMA-IR) tended to be greater in the group with Gleason scores of 7(4+3, pu003c0.01, suggesting greater insulin secretion, compared with those who had Gleason scores 6(3+3) and 7(3+4). Central adiposity measured by waist circumference, was significantly elevated (pu003c0.05) in those with the highest Gleason scores compared to those with lower Gleason scores (Gleason 7(4+3) or greater: 110.1 7.4 cm vs Gleason 7 (3+4): 102.0 9.5 cm). Men with the highest Gleason scores had significantly greater serum leptinlevels than those with lower Gleason scores (Gleason 7(4+3) or greater: 15604.4 3290.5 pg/mL vs Gleason 7(3+4): 8131.5 8069.7 pg/mL, pu003c0.05) and serum leptin:adiponectin ratio (Gleason 7(4+3) or greater: 2.4 2.1 AU vs Gleason 7(3+4): 2.9 3.2 AU, pu003c0.05). CONCLUSIONS: This is the first study to integratively show that serum c-peptide, visceral adiposity, serum leptin and leptin to :adiponectin ratio are associated with high Gleason scores, suggesting a cluster of obesity related metabolic perturbations that may contribute to aggressiveness in prostate cancer.