Exposition Orale Et Devenir Dans L’intestin Des Nanoparticules Alimentaires : Exemple De L’argent Et Du Dioxyde De Titane
Cahiers de nutrition et de diététique(2016)
摘要
Facing the growing use of nano-manufactured products in many consumer goods, including those from the agro-food sector, the consequences of chronic exposure in humans set public health issues. The oral route of exposure remains largely unknown although a nano-sized fraction of particles is found in food additives/supplements or incorporated into packaging in contact with food. Once ingested, nanoparticles may transit within the gastro-intestinal tract, be chemically and morphologically transformed, and impact the luminal environment before crossing the epithelial barrier and distributing to the systemic compartment. This review focuses on nano-silver and nano-titanium dioxide. Despite their specificities and differences, a close relationship exists between physico-chemical reactivity and bioavailability/biopersistence within the gut. Few data are to date reported on the interactions between nano-silver/nano-titanium dioxide, microbiota and mucus, which are key players in intestinal homeostasis and host health, with a putative impact on nanoparticle distribution to the systemic compartment. (C) 2016 Societe francaise de nutrition. Published by Elsevier Masson SAS. All rights reserved.
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关键词
Food nanoparticle,Silver,Titanium dioxyde,Mucus,Intestinal microbiota
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