Antithrombotic therapy after bioprosthetic aortic valve implantation: Warfarin versus aspirin, a randomized controlled trial ☆

•Largest randomized trial testing warfarin versus aspirin after bioprosthetic aortic valve•No difference in thromboembolic events between warfarin and aspirin•Warfarin therapy associated with significantly more bleeding•Difficult to maintain patients in therapeutic INR interval