H1:IC31 vaccination is safe and induces long-lived TNF-α+IL-2+CD4 T cell responses in M. tuberculosis infected and uninfected adolescents: A randomized trial

Helen Mearns,Hennie D. Geldenhuys,Benjamin M. Kagina,Munyaradzi Musvosvi,Francesca Little, Frances Ratangee,Hassan Mahomed,Willem A. Hanekom,Søren T. Hoff,Morten Ruhwald,Ingrid Kromann,Peter Bang,Mark Hatherill, Peter Andersen,Thomas J. Scriba,Virginie Rozot,Deborah A. Abrahams,Katya Mauff,Erica Smit, Yolande Brown,E. Jane Hughes, Edward Makgotlho,Alana Keyser,Mzwandile Erasmus,Lebohang Makhethe,Hadn Africa, Charles Hopley,Marcia Steyn

Vaccine（2017）

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摘要

•H1:IC31 vaccination was well tolerated and had an acceptable safety profile.•Two vaccinations of 15μg H1:IC31 induced the most durable immune response.•H1:IC31 induced long-lived memory CD4 T cells that co-express TNFα and IL-2.

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关键词

Randomised,Clinical trial,H1:IC31,Mycobacterium tuberculosis,Adolescents,Vaccine,ESAT-6,Ag85B

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