Chemotherapy In Metastatic Hormone-Naive Prostate Cancer: Pooled Analysis Of Randomized Clinical Trials.

259 Background: To assess the role of chemotherapy in metastatic, hormone-naive prostate cancer, we presents the preliminary data of a pooled analysis comparing the outcome of patients with metastatic hormone-naive prostate cancer. Methods: A pooled analysis of the outcome of randomized clinical trials approaching the role of docetaxel in metastatic hormone-naive prostate cancer was performed using a random effect model. The final outcome of all the patients enrolled into the trials was the primary end point of our analysis. The pooled final result was reported as pooled Hazard Ratio and 95% Confidence Interval. The between-the trials heterogeneity was assessed using the I2 test. An α-error of 5% was identified as index of statistical significance. Overall survival of the entire population enrolled into the trials was the outcome of the preliminary analysis, while no subgroup analysis was performed in this preliminary phase of a multi-steps analysis. Results: Three trials (the CHAARTED, the STAMPEDE and t...