Evaluation Of Single Nucleotide Polymorphisms Of Angiotensin Ii Type 2 Receptor (Agtr2) Gene And Interleukin 4 (Il-4) Gene For Their Contribution To The Risk Of Preeclampsia In Turkish Population

Purpose: Preeclampsia, specific to human pregnancies, is a serious disorder, which occurs approximately in 6-10% of all pregnancies. It is a complex disorder, in which immune and genetic factors also take part. The aim of the current study was toinvestigate whether there is an association between AGTR2 A1675G and IL4 -590 (C>T) polymorphisms and preeclampsia.Material and Methods: Genomic DNA was extracted from the peripheral venous blood of 131 preeclamptic and 86 normotensive pregnant women. The AGTR2 and IL-4 polymorphisms were genotyped by using a polymerase chain reaction assay.Results: As for AGTR2 gene 1675 polymorphism, there was not any significant difference in terms of genotype frequencies but there was a significant difference in terms of allele frequencies. As for IL-4 gene -590 polymorphism, there was not any significant difference in terms of genotype and allele frequencies.Conclusions: AGTR2, GG genotype and IL-4, TT genotype were found significantly higher in preeclamptic women than normotensive pregnant women. These genotypes might be a susceptibility risk factor for preeclampsia but these findings need to be tested in a larger sample size.