Rh-Catalyzed Transient Directing Group Promoted Ch Amidation Of Benzaldehydes Utilizing Dioxazolones
CHINESE JOURNAL OF CHEMISTRY(2018)
摘要
Transition-metal catalyzed CH functionalization of benzaldehydes is of great interest in organic synthesis. Herein, we developed a transient directing group assisted amidation of benzaldehydes catalyzed by rhodium catalyst. With the employment of 10 mol% of 4-trifluoromethyl aniline, the in situ generated imine groups as the directing group efficiently enable this transformation. By using this protocol, a wide range of benzaldehydes were efficiently converted into the corresponding N-(2-formylphenyl)benzamides utilizing dioxazolones as the nitrogen source.
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关键词
amidation, benzaldehydes, rhodium, CH functionalization, transient directing group
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