FRI0245 Predictors for clinically diagnosed gout – 30 years follow-up in the malmÖ preventive project cohort, sweden

Background Gout is the most common form of inflammatory arthritis worldwide. Hyperuricemia is a crucial risk factor. The relative importance of other risk factors is slightly more controversial. Objectives Our aim was to identify predictors for clinical gout cohort from a population survey, the Malmo Preventive Project (MPP) – a large-scale screening and case finding program in Malmo, Sweden. Methods A total of 33 346 individuals (67% men, mean age 46 years, mean follow-up 28 years) were screened 1974–1992. The survey included: A Questionnaire (alcohol consumption, smoking); A Physical Examination and Laboratory tests . The Malmo modification of Michigan alcoholism screenings test (Mm-MAST) was used to identify alcohol risk consumption (Mm-MAST score ≥2). Subjects were followed to date of first gout diagnosis, death, migration from area, or December 2014. All gout diagnoses given at visits to physicians in primary or specialised care were identified by linking MPP cohort to regional Skane Healthcare Register and to National Patient Register. Possible risk factors/markers at baseline associated with incident gout were analysed using Cox-regression models. Results In total, 1275 individuals (3.8%); 1014 men (4.5%) and 261 women (2.4%) were diagnosed with gout. In both sexes, baseline s-UA u003e405 (age-adjusted) was the strongest factor associated with incident gout. Higher age, higher BMI, higher s-triglycerides, hypertension and smoking were also associated with gout in both sexes. Mm-MAST score ≥2 was associated with gout only in men while higher ESR was associated with gout only in women (table 1). Conclusions In this large cohort of middle-age individuals, hyperuricemia, higher age, hypertriglyceridemia and higher BMI were associated with incident gout in both sexes. Alcohol risk consumption predicted gout only in men. Higher ESR, as a possible marker of chronic inflammation, was a significant predictor only in women. Disclosure of Interest None declared