Visualizing hydrogen peroxide in Parkinson’s disease models via a ratiometric NIR fluorogenic probe

Yi Liu,Lei Bai, Yihao Li,Yun Ni,Chenqi Xin,Chengwu Zhang,Jinhua Liu,Zhipeng Liu,Lin Li,Wei Huang

Sensors and Actuators B: Chemical（2019）

引用 30|浏览9

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摘要

•A new ratiometric and NIR fluorogenic probe (NIR-HP1) for detecting H2O2 in Parkinson’s disease models was developed.•NIR-HP1 shows specific H2O2-induced emission shift from visible light to NIR region.•NIR-HP1 has been utilized to realize the in vivo ratiometric H2O2 imaging in living cells and zebrafish.•NIR-HP1 was successfully applied to the detection of endogenous H2O2 in parkin-null Drosophila brain.

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关键词

Parkinson’s disease,Fluorescent sensing and imaging,Hydrogen peroxide,Ratiometric sensor,Near-infrared

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