Facile preparation and characterization of novel oleanane-type triterpene functionalized β-cyclodextrin conjugates

Four water-soluble β-CD-pentacyclic triterpene conjugates were synthesized via ester and amide linkages. All the conjugates showed lower hydrophobicity (AlogP) than their parent compounds while no significant cytotoxicity was found to HL-60, A549, Hela and Bel-7402 cells at concentrations up to 10 μmol/L. Further anti-HCV entry activity and mechanism studies are under way in our laboratory.