STRUCTURAL INTEGRITY IN SUBJECTIVE COGNITIVE DECLINE, MILD COGNITIVE IMPAIRMENT AND ALZHEIMER’S DISEASE BASED ON MULTICENTER DIFFUSION TENSOR IMAGING: RESULTS FROM THE DELCODE STUDY

were more likely to progress to MCI when compared to SDB-/Ab+ NL subjects (49% versus 42%). SDB+/AbNL subjects when compared to SDB-/AbNL subjects did not show significant difference in the progression rate (17% versus 16%). SDB+/Ab+ predicted shorter time-to-progression with adjusted hazard ratio (aHR) 1⁄4 1.16, 95% CI: 1.04, 1.32, p 1⁄4 0.03) compared to SDB-/ Absubjects. Being SDB+/Abdid not reveal significant differences in time-to-progression from NL to MCI when compared to SDB-/Absubjects (aHR) 1⁄4 1.01, 95% CI: 0.76, 1.26, p 1⁄4 0.10). Conclusions: Sleep Disordered Breathing and Brain beta-amyloid both predict time-to-progression from cognitive normal to mild cognitive impairment with brain beta-amyloid modifying the progression risk. Further studies with objective measures of SDB are needed to determine whether SDB severity increases the progression risk in cognitively normal elderly.