Modulation of eyeblink conditioning through sensory processing of conditioned stimulus by cortical and subcortical regions

•Sensory processing of conditioned signals to the cerebellum is essential for eyeblink conditioning (EBC)•A multiple-level network is required to modulate transmission of non-optimal signals at the pontine nucleus•The modulating network is composed of circuits originating from both cortical and subcortical regions•Whether mPFC is involved in EBC depends on the actual conditioned and unconditioned stimuli