Abstract 20172: A Novel Mutation in Hif1α in Sprague Dawley Rats is Associated With Hyper-Responsiveness to Su5416 and Severe Pulmonary Arterial Hypertension

Ketul R Chaudhary,Yupu Deng,Anli Yang, Edwin Cuppen,Duncan Stewart

Circulation（2016）

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摘要

Introduction: Our lab has identified a unique sub-strain of SD rats that is hyper-responsive (HR) to SU5416 (SU) alone and develops severe progressive PAH in response to single injection of SU, eve...

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pulmonary arterial hypertension,hif1α,novel mutation,severe pulmonary,hyper-responsiveness

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