2395. Mechanism-Based-Susceptibility Testing (MBST) Using Disc Diffusion Assays (DDA) to Guide Treatment of Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa (MDR-XDR-Pa) in a Cystic Fibrosis (CF) Lung Transplant Recipient; Are We Ready for Combination Therapy vs. MDR-XDR-Pa?

Lilian M Abbo,Mohamad Yasmin,Steven H Marshall,Federico Perez, Mónica Corzo-Pedrosa,Jose F Camargo,Jacques Simkins,Laura Aragon,Shweta Anjan,Michele I Morris,Nicolas Brozzi, Mathias Loebe,Jesse Fulmer,Neeraj Sinha,Octavio Martinez,Armando Perez-Cardona,Andrew Colin, Christina Cloke,Robert A Bonomo

Open Forum Infectious Diseases（2018）

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摘要

Background Lung infections with MDR-XDR-Pa in patients with CF are challenging due to the emergence of antibiotic resistance. We applied MBST with DDA to guide combination antibiotic therapy in an 18-year-old woman with CF. We investigated if this approach can assist in choosing effective regimens.

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