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Costs of COPD Exacerbations in a General Population.

European Respiratory Journal(2018)SCI 1区

Univ Bergen | University of Bergen

Cited 5|Views69
Abstract
Background: Studies on costs of COPD exacerbations from general populations are scarce. Objectives: To compare direct costs (treatment-related) and indirect costs (productivity-related) associated with COPD in population based and hospital-recruited samples, and to estimate the components related to moderate and severe exacerbations. Methods: We performed 4 telephone interviews with 81 COPD cases and 132 controls from a population-based survey and 205 hospital-recruited COPD-patients. A moderate exacerbation was defined by use of antibiotics or corticosteroids due to respiratory disease, and severe exacerbations by hospitalisation due to respiratory disease. The sum of direct and indirect costs gave the total costs. Initial analyses compared costs across the three groups, and multivariate quantile regression estimated the costs attributed to exacerbations. Results: The crude, annual mean total disease-related costs were €26518, €15021, and €6740 per person for the patients, cases, and controls (p<0.001), respectively. In multivariate analyses exacerbations explained a majority of both direct and indirect costs of COPD. Severe exacerbations accounted for €28329 (95% CI 11467, 45192) of the total costs of population based COPD. For hospital-recruited COPD patients, both moderate and severe exacerbations were significant cost drivers accounting for €3034 (467, 5600) and €8527 (3912, 13141) of the total costs. Among hospital-recruited COPD patients, increasing GOLD-stage was also significantly associated with elevated costs. Conclusion: The annual total health-related costs for a hospital-recruited COPD-patient were nearly twice that of a general population-based COPD-case. The most important cost driver was severe exacerbations.
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要点】:该论文比较了基于人群和医院招募的COPD样本的直接(治疗相关)和间接(生产率相关)费用,并估计了与中度或重度加重相关的组成部分。

方法】:通过电话访谈进行研究,对81名COPD病例和132名对照组成员进行调查,以及对205名医院招募的COPD患者进行研究。

实验】:研究使用了一个由人群基础调查组成的数据集,分析了中度(使用抗生素或皮质类固醇治疗呼吸道疾病)和重度(因呼吸道疾病住院)加重的费用,结果显示,加重的费用在COPD的直接和间接总费用中占有很大比例,且对于医院招募的COPD患者,加重的级别与费用增加呈正相关。