Force spectroscopy of the thrombin-aptamer interaction: Comparison between AFM experiments and molecular dynamics simulations

Xiao Ma,Agnivo Gosai,Ganesh Balasubramanian,Pranav Shrotriya

Applied Surface Science（2019）

引用 6|浏览6

暂无评分

摘要

•DFS experiment and MD simulation are combined to study thrombin-aptamer binding.•Multiple factors affecting force measurement are comprehensively elucidated.•Enhanced analytical techniques are employed to determine dissociation force quanta.•Dissociation force of the complex is lower than that of G-quadruplex breakdown.

查看译文

关键词

Dynamic force spectroscopy,Atomic force microscopy,Single energy barrier model,Molecular dynamics,Thrombin,Aptamer

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要