An Accessible and Unique Insight into Metastasis Mutational Content Through Whole-exome Sequencing of Circulating Tumor Cells in Metastatic Prostate Cancer

Vincent Faugeroux,Céline Lefebvre,Emma Pailler,Valérie Pierron,Charles Marcaillou, Sébastien Tourlet,Fanny Billiot,Semih Dogan,Marianne Oulhen,Philippe Vielh,Philippe Rameau,Maud NgoCamus,Christophe Massard,Corinne Laplace-Builhé, Arian Tibbe,Mélissa Taylor,Jean-Charles Soria,Karim Fizazi,Yohann Loriot,Sylvia Julien

European Urology Oncology（2020）

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摘要

Genomic analysis of circulating tumor cells (CTCs) can provide a unique insight into metastasis mutational diversity and reveal undiagnosed aberrations in matched metastasis biopsies from patients with castration-resistant prostate cancer. Our findings emphasize the clinical potential of detection of such aberrations in CTCs via minimally invasive blood draws.

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Circulating tumor cells,Liquid biopsy,Prostate cancer,Whole-exome sequencing

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