A review of GI conditions critical to oral drug absorption in malnourished children
European Journal of Pharmaceutics and Biopharmaceutics(2019)
摘要
Accurate prediction of oral absorption of drugs relies on biorelevant methodology. Current methods are based on Western healthy adult populations. Malnourished children have many differences in their gastrointestinal anatomy and physiology compared to a healthy Western adult. These differences may affect the oral absorption of medicines and it is important to gather knowledge on these GI differences in order to develop biorelevant predictive methods for this vulnerable population.
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关键词
Malnourished,Biopharmaceutics,Children,Absorption,Gastrointestinal physiology
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