Targets and mechanisms of chemically induced aneuploidy. Part 1 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases

Anthony M. Lynch,David Eastmond,Azeddine Elhajouji,Roland Frötschl,Micheline Kirsch-Volders,Francesco Marchetti,Kenichi Masumura,Francesca Pacchierotti,Maik Schuler,David Tweats

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2019）

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摘要

•Describes mechanism of aneuploidy induction.•Discusses methods to detect aneugens.•Discusses the regulatory framework for the assessment of aneugens.•Uses AOPs to describe MOA information for tubulin binders and aurora B inhibitors.

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