MICROVASCULAR ENDOTHELIAL FUNCTION DIFFERS BETWEEN HEART FAILURE WITH PRESERVED EJECTION FRACTION PHENOTYPES

Andreas Gevaert, Birgit Boehm, Flavia Baldassarri,Inge Goovaerts,Tibor Stoop, Haley Hartmann,Stephan Mueller,Andre Duvinage,Elisabeth Kraigher-Krainer,Caroline M. Van De Heyning,Paul J. Beckers,Ulrik Wisloff,Burkert Pieske,Ephraim B. Winzer,Martin Halle,Emeline M. Van Craenenbroeck

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY（2019）

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摘要

Phenotypical heterogeneity among patients could be a reason why prognosis of heart failure with preserved ejection fraction (HFpEF) has not been improved in clinical trials. Vascular dysfunction is considered a central mediator in HFpEF pathophysiology, but its clinical detection has shown mixed

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