Research status and progress of inhibitory effects and inhibitory mechanism of complex-type urease inhibitors - a review

The widespread presence of urease in agricultural settings places enormous pressure on the soil environment. Urease inhibitors have been used as promising biochemical methods in reducing urease efficiency to ensure food security and agricultural sustainability. Compared with metal salts, organic products and plant extracts, complex-type urease inhibitors are low toxic, highly inhibitory and stable.They have become a hot topic of research for domestic and foreign scholars. This article reviews the status of research into complex-type urease inhibitors, expounds their dynamic and thermodynamic mechanisms and summarizes the mechanistic research carried out to date. Some prospects for and disadvantages of using complex-type urease inhibitors have been proposed.