Metal-free and efficient approach to 4-thiocyanated 2H-chromenes via TFA-mediated cascade cyclization of 2-propynolphenols

Tetrahedron Letters(2019)

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摘要
•TFA mediated synthesis of 4-thiocyanated 2H-chromenes in good to excellent yields.•The 4-thiocyanated 2H-chromenes are versatile intermediates in organic synthesis.•This approach can be enlarged to gram scale.•This process involves a SCN-containing alleneyl intermediate through SN1 way.
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关键词
2-Propynolphenols,4-Thiocyanated 2H-chromenes,TFA-mediated,Cascade cyclization
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