Ocular biopharmaceutics: impact of modeling and simulation on topical ophthalmic formulation development
Drug Discovery Today(2019)
摘要
•Historical and emerging computational tools to support ophthalmic drug discovery.•Preclinical ocular pharmacokinetics burden animal use, while clinically impractical.•Therapeutic bioequivalence studies between ophthalmic products are challenging.•Topical and injectable ophthalmic products require full disposition understanding.
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