Efficient and stereoselective synthesis of thiosulfinates from disulfide using cumene hydroperoxide in the presence of titanium-based catalyst systems

An efficient and stereoselective procedure of oxidizing disulfide to thiosulfinate 2a using CHP as the oxidant and economically available Ti(O-i-Pr)(4)/L-DET/H2O as catalysts were developed. The reaction went smoothly under mild conditions with synthetic useful yield and the workup for obtaining the final product is quite convenient.