The Ryanodine Receptor Stabilizer S44121 / Arm036 Improves Peripheral and Respiratory Muscle Function in a Mouse Model of Heart Failure

Marion Pauly,Stefan Matecki,Jerome Thireau,Muriel Bouly,Jerome Roussel,Sylvain Richard,Alain Lacampagne

Circulation（2014）

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摘要

Background: Congestive heart failure (CHF) is associated with progressive skeletal muscle dysfunction (reduced exercise capacity and increased fatigability). Type 1 ryanodine receptor (RyR1) is the...

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关键词

Calcium Cardiovascular therapeutics Experimental heart failure Muscle,skeletal Excitation-contraction coupling (ECC)

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