Use of phentermine/topiramate extended release in combination with sleeve gastrectomy in patients with BMI 50 kg/m2 or more

1-This is a report of a pilot trial designed to test the feasibility and impact of using phentermine/topiramate extended release (phen/top) pre and postoperatively in patients with super obesity undergoing sleeve gastrectomy (LSG).2-The phen/top treatment group lost over 2 times as much weight (28.1±12.8 kg vs 12.3±12.5 kg) during preoperative treatment as compared to controls.3-At 2 years, there was an excess weight loss percent difference of -18.2% (95% CI, -32.1, -4.4) that favored the phen/top treatment group.4-In patients with super obesity, a higher proportion treated with phen/top plus LSG treatment compared to LSG alone achieved a BMI <40 kg/m2 at 2 years of treatment.