Abstract 14209: Association Between Atrial Septal Defects and Bronchopulmonary Dysplasia in Premature Infants

Introduction:Bronchopulmonary dysplasia (BPD) is a major cause of morbidity and mortality affecting 20,000 infants in the United States yearly. Known BPD risk factors include prematurity, respiratory support, oxygen use, and the presence of a patent ductus arteriosus (PDA). PDA increases BPD risk due to increased pulmonary blood flow which also occurs in the presence of an atrial septal defect (ASD). The extent to which an ASD impacts the risk of BPD is largely unknown. Hypothesis: Evaluate the association between ASD and BPD risk in premature infants. Methods: We used electronic medical record data from u003e950,000 infants in 362 neonatal intensive care units (NICUs) in the US managed by Pediatrix Medical Group (2004 - 2013) to identify infants 24-30 weeks gestational age (GA) and u003c1250 g birth weight (BW). We excluded infants with major anomalies including heart defects other than ASD or PDA. We defined BPD as the need for supplemental oxygen or respiratory support continuously from corrected GA 36-0 to 36...