14-3-3s function in plant cadmium response by changes of glutathione and glutathione synthesis in Arabidopsis

•14-3-3 κ and λ negatively regulate plant Cd tolerance.•14-3-3 κ and λ decrease the accumulation of GSH and PC by modulating the synthesis gene expression under Cd stress.•14-3-3 κ and λ function in plant Cd response by affecting H2O2 content through changes of GSH accumulation.