MP69-12 SURGERY FOR RECURRENT ADRENOCORTICAL CARCINOMA: A RETROSPECTIVE SINGLE-CENTER STUDY

You have accessJournal of UrologyAdrenal (MP69)1 Apr 2019MP69-12 SURGERY FOR RECURRENT ADRENOCORTICAL CARCINOMA: A RETROSPECTIVE SINGLE-CENTER STUDY Kan Wu*, Zhihong Liu, Jiayu Liang, Chuan Zhou, Fuxun Zhang, Fan Zhang, Yiping Lu, and Yuchun Zhu Kan Wu*Kan Wu* More articles by this author , Zhihong LiuZhihong Liu More articles by this author , Jiayu LiangJiayu Liang More articles by this author , Chuan ZhouChuan Zhou More articles by this author , Fuxun ZhangFuxun Zhang More articles by this author , Fan ZhangFan Zhang More articles by this author , Yiping LuYiping Lu More articles by this author , and Yuchun ZhuYuchun Zhu More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000557045.78498.d5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Adrenocortical carcinoma (ACC) is a rare but deadly malignancy with a high rate of recurrence. Surgery remains the only potentially curative option for ACC, while its role for recurrent disease is controversial. We summarized the outcomes of patients with recurrent ACC in our hospital. METHODS: This study retrospectively reviewed all patients with recurrent ACC, managed in our institution between 2009 and 2017. All available clinicopathologic data and follow-up outcomes were collected. Kaplan-Meier method and Cox proportional hazards model were used to evaluated survival outcome according to treatment for recurrent disease. RESULTS: Thirty-four cases were included. Twelve patients underwent reoperation for recurrence, while 22 had nonoperative therapy. Baseline patient characteristics (age, gender, hormonal secretion, tumor stage Ki-67%, and Weiss score) were similar between two groups. Operated patients had greater median overall survival after recurrence than nonoperated patients (25 vs 6 months; p = 0.046). In nonoperated patients, adjuvant treatment did not impact overall survival. Surgery for recurrence (p = 0.039) and a Ki-67 < 25% (p = 0.007) were both prognostic factors for improved survival, whereas age, gender, stage, tumor size and disease-free interval between initial resection and recurrence > 12 months were not. CONCLUSIONS: In selected patients with recurrent ACC can benefit from surgical approach with improvement in survival. Ki-67 index is an important prognostic factor of survival in patients with recurrent disease. Source of Funding: none Chengdu, China, People’s Republic of© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e988-e989 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kan Wu* More articles by this author Zhihong Liu More articles by this author Jiayu Liang More articles by this author Chuan Zhou More articles by this author Fuxun Zhang More articles by this author Fan Zhang More articles by this author Yiping Lu More articles by this author Yuchun Zhu More articles by this author Expand All Advertisement PDF downloadLoading ...